The ALS Therapy Development Institute (ALS TDI)and its scientists actively discover and develop treatments for ALS. It is the world's first and largest nonprofit biotech focused 100 percent on ALS research. Led by people with ALS and their families, the Institute understands the urgent need to slow and stop this disease. Learn more


Stephen Heywood was diagnosed with ALS at age 29. After finding no treatment options, his brother, James Allen Heywood, realized that a gap existed in the preclinical development of therapeutics for ALS. In 1999, he founded the ALS Therapy Development Institute in the basement of his family’s Newton, MA home to bring effective treatments to people living with ALS as quickly as possible. Although Stephen is no longer with us, this same sense of hope and family drives every decision made at the Institute today.


ALS TDI's unique and comprehensive approach leverages over fifteen years of treatment-focused ALS research and applies it on an industrial scale to get therapeutics to people with ALS as quickly, efficiently, and cost-effectively as possible. The translational research environment brings together more than 30 fulltime scientists whose expertise include assay development, computational and molecular biology, pharmacology, and protein biochemistry. Dr. Steve Perrin, CEO and Chief Scientific Officer, frequently speaks about our research plan to patients, families, industry executives, and academics worldwide.

Recently, the Institute has identified AT-1501, a promising potential treatment for ALS. Addtionally, ALS TDI pioneered the ALS Precision Medicine Program (PMP), the world's premier program and partnership with ALS patients to discover additional potential treatments.

Learn more about research here.


Created in 2009 by people living with ALS who received their diagnosis before their 35th birthdays, the Young Faces of ALS (YFALS) campaign is the first community for young people afflicted by ALS, as well as their families and friends.

The purpose of the Young Faces of ALS program is to create an engaging online community of young people committed to raising awareness for ALS and to promote the work of ALS Therapy Development Institute to discover and develop effective treatments for ALS patients today. Learn more

Corntoss Challenge

Since 2011, the YFALS National Corntoss Challenge has successfully brought Cornhole enthusiasts along with ALS patients and their families, friends, and supporters together for a fun-filled day of Corntoss and good company to achieve one goal: end ALS. Every dollar supports the Young Faces of ALS (YFALS) campaign, benefiting research at the ALS Therapy Development Institute. Learn more


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